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Characteristics
 Morphology
Member of the Adenoviridae family, non-enveloped double- stranded DNA virus
Disease

Typically, self-limiting mild respiratory illness. Also childhood febrile illness and pharyngoconjunctival fever, Pneumonia, and other acute respiratory illnesses, Pertussis-like illness, Conjunctivitis, Upper respiratory illness, and hepatitis.
Zoonosis
None
Health Hazards
Host Range Humans.
Modes of Transmission
Respiratory and fecal-oral routes. Infection can also spread through contaminated fomites, fingers, ophthalmic solutions, and airborne particulates.
Signs and Symptoms 
Fever, nasal congestion, coryza, and pharyngitis.
Infectious Dose
Inhalation of as few as 5 adenovirus particles can cause disease in susceptible individuals.
Incubation Period 
Approximately 2 to 14 days.
Medical Precautions/Treatment
Prophylaxis
None available.
Vaccines
None available.
Treatment
Cidofovir has been reported to be effective but no controlled trails have been performed.
Surveillance
Monitor for symptoms.
MSU Requirements
Report any exposures.
Laboratory Hazards
Laboratory Acquired Infections (LAIs)
10 cases of laboratory acquired infections have occurred up to 2006.
 Sources

Cultures, frozen stocks, other samples described in IBC protocol.
Supplemental References
Canadian MSDS: http://www.phac-aspc.gc.ca/lab-bio/res/psds-ftss/index-eng.php
BMBL https://www.cdc.gov/labs/bmbl/?CDC_AAref_Val=https://www.cdc.gov/labs/BMBL.html
CDC https://www.cdc.gov/adenovirus/index.html 
NIH Guidelines https://osp.od.nih.gov/wp-content/uploads/NIH_Guidelines.pdf
Risk Group & Containment Requirements
Risk Group 2

Agents that are associated with human disease which is rarely serious and for which preventive or therapeutic interventions are often available.
BSL2
For all procedures involving suspected or known infectious specimen or cultures.
ABSL2
For all procedures involving animals infected with Adenovirus.
Spill Procedures
Small
Notify others working in the lab. Remove PPE and don new PPE. Cover area of the spill with absorbent material and add fresh 1:10 bleach:water. Allow 20 munutes (or as directed) of contact time. After 20 minutes, cleanup and dispose of materials.
Large
  • Immediately notify all personnel in the lab and clear all personnel from the area. Remove any contaminated PPE/clothing and leave the lab. 
  • Secure the area by locking doors, posting signage and guarding the area to keep people out of the space. 
For assistance, contact MSU's Biosafety Officer (406-994-6733) or Safety and Risk Management (406-994-2711).
Exposure Procedures
Mucous membrane
Flush eyes, mouth, or nose for 5 minutes at eyewash station.
Other Exposures
Wash area with soap and water for 5 minutes.
Reporting
Immediately report incident to supervisor, complete a First Report of Injury form, and submit to Safety and Risk Management.
Medical Follow-up
During business hours: Bridger Occupational Health 3406 Laramie Drive. Weekdays 8am -6pm.  Weekends 9am-5pm
After business hours: Bozeman Deaconess Hospital Emergency Room 915 Highland Blvd Bozeman, MT
Viability
Disinfection
1:5 dilution of bleach, accelerated hydrogen peroxide, or with 70% alcohol. Other disinfectants outlined by the EPA.  
Inactivation
Inactivated by moist heat (15 minutes at 121°C) and dry heat (56°C for 30 minutes).
Survival Outside Host
Stable at 36°C for a week, several weeks at room temperature, several months at 4°C, and 7 days to 3 months on dry surfaces.
Personal Protective Equipment (PPE)
Minimum PPE Requirements
Lab coat, disposable gloves, safety glasses, closed toed shoes, long pants
Additional Precautions
 Additioanl PPE may be required depending on lab specific SOPs and IBC Protocol.