When citing a core facility, please ensure that you are referrencing their Research Resource Identifier (RRID) number, and funding source. A citation example for the Cryo-EM facility is provided below:

"Funding to establish the cryo-EM core facility (RRID:SCR_026324) was provided by the National Science Foundation, the Murdock Charitable Trust, and MSU's Office of Research and Economic Development, and Graduate Education"

If users work closely with a member of facility staff on a project, they are expected to be viewed as collaborators. Please include them in attributions, and in relevant project meetings.

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View 2024-2025 publications.

Structures Determined by Facility Users

Structure of the Retron IA Complex without the HNH Nuclease

Structure of the Retron IA Complex without the HNH Nuclease

PDB ID: 9N6C

DOI: https://doi.org/10.1101/2025.03.26.645336

Structure of the retron IA complex with HNH nuclease in the "up" orientation

Structure of the retron IA complex with HNH nuclease in the "up" orientation

PDB ID: 9N6B

DOI: https://doi.org/10.1101/2025.03.26.645336

Structure of the retron IA complex with HNH nuclease in the "down" orientation

Structure of the retron IA complex with HNH nuclease in the "down" orientation

PDB ID: 9N69

DOI: https://doi.org/10.1101/2025.03.26.645336

Cryo-EM structure of the trimeric SenDRT9 RT-ncRNA complex (GST fusion)

Cryo-EM structure of the trimeric SenDRT9 RT-ncRNA

PDB ID: 9NLX

DOI: https://doi.org/10.1038/s41586-025-09179-5

Cryo-EM structure of hexameric SenDRT9 RT-ncRNA complex

Cryo-EM structure of hexameric SenDRT9 RT-ncRNA complex

PDB ID: 9NLV

DOI: https://doi.org/10.1038/s41586-025-09179-5

Asymmetric unit of the PARIS Immune Complex at 3.2 Angstrom Resolution

Asymmetric unit of the PARIS Immune Complex at 3.2 Angstrom Resolution

PDB ID: 8UX9

DOI: https://doi.org/10.1038/s41586-024-07874-3

Cas1-Cas2/3 integrase and IHF bound to CRISPR leader, repeat and foreign DNA

Cas1-Cas2/3 integrase and IHF bound to CRISPR leader, repeat and foreign DNA

PDB ID: 8FLJ

DOI: https://doi.org/10.1038/s41594-023-01097-2

 

2024-2025 Publications

*Henriques WS, Bowman J, Hall LN, Gauvin CC, Wei H, Kuang H, Zimanyi CM, Eng ET, Santiago-Frangos A, Wiedenheft B (2025 Jun 11). Structures reveal how the Cas1-2/3 integrase captures, delivers, and integrates foreign DNA into CRISPR loci bioRxiv, (), 2025.06.10.658980. . PMCID: 12259127.

Tang S, Žedaveinytė R, Burman N, Pandey S, Ramirez JL, Kulber LM, Wiegand T, Wilkinson RA, Ma Y, Zhang DJ, Lampe GD, Berisa M, Jovanovic M, Wiedenheft B, Sternberg SH (2025 May 28). Protein-primed homopolymer synthesis by an antiviral reverse transcriptase. Nature, (), . doi: 10.1038/s41586-025-09179-5. ID: 40436039.

*Brzozowski RS, Schmidt AK, Pershing NL, Dankwardt A, Faith DR, Joyce AC, Maciver A, Henriques WS, Andersen SE, Wiedenheft B, Casjens SR, Duerkop BA, Round JL, Secor PR (2025 May 6). A prophage-encoded sRNA limits lytic phage infection of adherent-invasive E. coli. bioRxiv : the preprint server for biology, (), . . ID: 40654919.

George JT, Burman N, Wilkinson RA, de Silva S, McKelvey-Pham Q, Buyukyoruk M, Dale A, Landman H, Graham A, DeLuca SZ, Wiedenheft B (2025 Mar 26). Structural basis of antiphage defense by an ATPase-associated reverse transcriptase. bioRxiv : the preprint server for biology, (), . . ID: 40196496.

Sobolewski TN, Trousdale RC, Gauvin CL, Lawrence CM, Walker RA (2025 Jan 14). Nanomolar PFOA Concentrations Affect Lipid Membrane Structure: Consequences for Bioconcentration Mechanisms. Environmental science & technology, 59(1), 709-718. doi: 10.1021/acs.est.4c03652. ID: 39718541.

Burman N, Belukhina S, Depardieu F, Wilkinson RA, Skutel M, Santiago-Frangos A, Graham AB, Livenskyi A, Chechenina A, Morozova N, Zahl T, Henriques WS, Buyukyoruk M, Rouillon C, Saudemont B, Shyrokova L, Kurata T, Hauryliuk V, Severinov K, Groseille J, Thierry A, Koszul R, Tesson F, Bernheim A, Bikard D, Wiedenheft B, Isaev A (2024 Dec). Author Correction: A virally encoded tRNA neutralizes the PARIS antiviral defence system. Nature, 636(8043), E8. . ID: 39633059.

Sobolewski TN, Findlay JL, Hemphill JE, Walker RA (2024 Nov 26). Aggregation, Not Micellization: Perfluorooctanoic Acid, Perfluorobutanesulfonic Acid, and Potassium Perfluorooctanesulfonate Behavior in Aqueous Solution. Langmuir : the ACS journal of surfaces and colloids, 40(47), 24820-24831. doi: 10.1021/acs.langmuir.4c02566. ID: 39539066.

Burman N, Belukhina S, Depardieu F, Wilkinson RA, Skutel M, Santiago-Frangos A, Graham AB, Livenskyi A, Chechenina A, Morozova N, Zahl T, Henriques WS, Buyukyoruk M, Rouillon C, Saudemont B, Shyrokova L, Kurata T, Hauryliuk V, Severinov K, Groseille J, Thierry A, Koszul R, Tesson F, Bernheim A, Bikard D, Wiedenheft B, Isaev A (2024 Oct). A virally encoded tRNA neutralizes the PARIS antiviral defence system. Nature, 634(8033), 424-431. . ID: 39111359.

Santiago-Frangos A, Henriques WS, Wiegand T, Gauvin CC, Buyukyoruk M, Graham AB, Wilkinson RA, Triem L, Neselu K, Eng ET, Lander GC, Wiedenheft B (2023 Nov). Structure reveals why genome folding is necessary for site-specific integration of foreign DNA into CRISPR arrays. Nature structural & molecular biology, 30(11), 1675-1685. . ID: 37710013.